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Combined Serological and Psychological Assessment of Anxiety in Anxiety Patients

M. Kogler

Anxiety disorders, especially panic attacks can be artificially evoked by several substances, some of them so called „metabolic panickogenes“ like lactate, CO2 and HCO3. They alter pH values , stimulate breathing frequency and thus create a model for panic attacks. Another group of substances involves the noradrenergic and serotoninergic system. They partly act via the Hypothalamic – Hypophyseal – Adrenaocortical System (HPA). This group of substances may be seen as a model for the generalized anxiety disorder. The panic and anxiety creating potency of both groups is well investigated. Much less is known about the metabolic and noradrenergic/serotoninergic situation of patients at the beginning of psychotherapy, whose anxiety disorders are not provoked by those substances.

Therefore our study investigates how changing patterns of lactate, baseexcess, CO2, HCO3, pO2, electrolytes a.s.o. do differ between each other, according to differing provocations (physical workload, biofeedback, relaxation) in anxiety patients and control persons. According to the ability of additive secretion of catecholamines, striking differences between cumulating catecholamine effects (see above) in anxiety patients and control persons due to the same sort of provocation could be seen.

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